Dr. Mario games feature a grid that starts out partially filled with viruses of three colors (red, yellow and blue) that Dr. Mario must destroy with pills called Megavitamins of the same color. The game's speed and level of difficulty can be adjusted before the game, but each will increase as the game progresses. A 2-player competitive game is also available, in which the first player to clear all of his or her viruses before their opponent does wins.